N-苯基哌嗪

N-苯基哌嗪
	IUPAC名; 1-Phenylpiperazine
识别
CAS号	92-54-6
PubChem	7096
ChemSpider	6829
SMILES	c1cc(ccc1)N2CCNCC2;
性质
化学式	C10H14N2
摩尔质量	162.23 g/mol g·mol⁻¹
外观	无色至黄色液体
密度	1.028 g/cm3
熔点	18.8 °C（292 K）
沸点	287.2 °C（560 K）
溶解性（水）	10 g（25 °C）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

N-苯基哌嗪是一种有机化合物，化学式为C₁₀H₁₄N₂。它可由氯苯和哌嗪在叔丁醇钾的存在下于二氧六环中反应得到，^[2]也有文献以溴苯为原料、氢氧化钠为碱进行反应。^[3]它的哌嗪环一段的N-H还能继续发生反应，如和2-氯-6-甲基吡啶在碱的存在下反应，得到1-(6-甲基吡啶-2-基)-4-苯基哌嗪。^[4]

参考文献

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-10]
^ Muthukumaran Nirmala, Gandhi Saranya, Periasamy Viswanathamurthi, Roberta Bertani, Paolo Sgarbossa, Jan Grzegorz Malecki. Organonickel complexes encumbering bis-imidazolylidene carbene ligands: Synthesis, X-ray structure and catalytic insights on Buchwald-Hartwig amination reactions. Journal of Organometallic Chemistry. 2017-03, 831: 1–10 [2021-04-10]. doi:10.1016/j.jorganchem.2016.12.029. （原始内容存档于2020-02-16）（英语）.
^ Atul Kumar, Ajay Kumar Bishnoi. Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water. RSC Advances. 2015, 5 (26): 20516–20520 [2021-04-10]. ISSN 2046-2069. doi:10.1039/C4RA15267K （英语）.
^ Fei-Dong Huang, Chang Xu, Dong-Dong Lu, Dong-Sheng Shen, Tian Li, Feng-Shou Liu. Pd-PEPPSI-IPent An Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions. The Journal of Organic Chemistry. 2018-08-17, 83 (16): 9144–9155 [2021-04-10]. ISSN 0022-3263. doi:10.1021/acs.joc.8b01205. （原始内容存档于2021-12-15）（英语）.

[1] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-10]

[2] Muthukumaran Nirmala, Gandhi Saranya, Periasamy Viswanathamurthi, Roberta Bertani, Paolo Sgarbossa, Jan Grzegorz Malecki. Organonickel complexes encumbering bis-imidazolylidene carbene ligands: Synthesis, X-ray structure and catalytic insights on Buchwald-Hartwig amination reactions. Journal of Organometallic Chemistry. 2017-03, 831: 1–10 [2021-04-10]. doi:10.1016/j.jorganchem.2016.12.029. （原始内容存档于2020-02-16）（英语）.

[3] Atul Kumar, Ajay Kumar Bishnoi. Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water. RSC Advances. 2015, 5 (26): 20516–20520 [2021-04-10]. ISSN 2046-2069. doi:10.1039/C4RA15267K （英语）.

[4] Fei-Dong Huang, Chang Xu, Dong-Dong Lu, Dong-Sheng Shen, Tian Li, Feng-Shou Liu. Pd-PEPPSI-IPent An Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions. The Journal of Organic Chemistry. 2018-08-17, 83 (16): 9144–9155 [2021-04-10]. ISSN 0022-3263. doi:10.1021/acs.joc.8b01205. （原始内容存档于2021-12-15）（英语）.

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