拉尼兰诺

拉尼兰诺
识别信息
	IUPAC命名法 4-[1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid; ;
CAS号	927961-18-0
PubChem CID	68677842;
UNII	28Q8AG0PYL;
ECHA InfoCard	100.218.645
化学信息
化学式	C19H15ClN2O4S2
摩尔质量	434.91 g·mol−1

拉尼兰诺是一种泛PPAR 激动剂，是第一种同时针对PPAR-α、PPAR-β和PPAR-γ的靶向药物。^[1]^[2]^[3]截至2023年，正在进行非酒精性脂肪性肝炎的III期试验；与针对相同病症进行III期试验的其他药物相比，其优势在于它对脂肪性肝炎和纤维化都有改善作用。^[4]

参考文献

^ Derrett-Smith, Emma; Clark, Kristina E. N.; Shiwen, Xu; Abraham, David J.; Hoyles, Rachel K.; Lacombe, Olivier; Broqua, Pierre; Junien, Jean Louis; Konstantinova, Irena; Ong, Voon H.; Denton, Christopher P. The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis. Arthritis Research & Therapy. 6 September 2021, 23 (1): 234 [2023-11-23]. ISSN 1478-6362. doi:10.1186/s13075-021-02592-x . （原始内容存档于2023-11-23）.
^ Boyer-Diaz, Zoe; Aristu-Zabalza, Peio; Andrés-Rozas, María; Robert, Claude; Ortega-Ribera, Martí; Fernández-Iglesias, Anabel; Broqua, Pierre; Junien, Jean-Louis; Wettstein, Guillaume; Bosch, Jaime; Gracia-Sancho, Jordi. Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease. Journal of Hepatology. May 2021, 74 (5): 1188–1199. doi:10.1016/j.jhep.2020.11.045 .
^ Francque, Sven M.; Bedossa, Pierre; Ratziu, Vlad; Anstee, Quentin M.; Bugianesi, Elisabetta; Sanyal, Arun J.; Loomba, Rohit; Harrison, Stephen A.; Balabanska, Rozalina; Mateva, Lyudmila; Lanthier, Nicolas; Alkhouri, Naim; Moreno, Christophe; Schattenberg, Jörn M.; Stefanova-Petrova, Diana; Vonghia, Luisa; Rouzier, Régine; Guillaume, Maeva; Hodge, Alexander; Romero-Gómez, Manuel; Huot-Marchand, Philippe; Baudin, Martine; Richard, Marie-Paule; Abitbol, Jean-Louis; Broqua, Pierre; Junien, Jean-Louis; Abdelmalek, Manal F. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH. New England Journal of Medicine. 21 October 2021, 385 (17): 1547–1558 [2023-11-23]. ISSN 0028-4793. doi:10.1056/NEJMoa2036205 . （原始内容存档于2023-11-23）（英语）.
^ Harrison, Stephen A.; Loomba, Rohit; Dubourg, Julie; Ratziu, Vlad; Noureddin, Mazen. Clinical Trial Landscape in NASH. Clinical Gastroenterology and Hepatology. July 2023, 21 (8): 2001–2014. doi:10.1016/j.cgh.2023.03.041.

[1] Derrett-Smith, Emma; Clark, Kristina E. N.; Shiwen, Xu; Abraham, David J.; Hoyles, Rachel K.; Lacombe, Olivier; Broqua, Pierre; Junien, Jean Louis; Konstantinova, Irena; Ong, Voon H.; Denton, Christopher P. The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis. Arthritis Research & Therapy. 6 September 2021, 23 (1): 234 [2023-11-23]. ISSN 1478-6362. doi:10.1186/s13075-021-02592-x . （原始内容存档于2023-11-23）.

[2] Boyer-Diaz, Zoe; Aristu-Zabalza, Peio; Andrés-Rozas, María; Robert, Claude; Ortega-Ribera, Martí; Fernández-Iglesias, Anabel; Broqua, Pierre; Junien, Jean-Louis; Wettstein, Guillaume; Bosch, Jaime; Gracia-Sancho, Jordi. Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease. Journal of Hepatology. May 2021, 74 (5): 1188–1199. doi:10.1016/j.jhep.2020.11.045 .

[3] Francque, Sven M.; Bedossa, Pierre; Ratziu, Vlad; Anstee, Quentin M.; Bugianesi, Elisabetta; Sanyal, Arun J.; Loomba, Rohit; Harrison, Stephen A.; Balabanska, Rozalina; Mateva, Lyudmila; Lanthier, Nicolas; Alkhouri, Naim; Moreno, Christophe; Schattenberg, Jörn M.; Stefanova-Petrova, Diana; Vonghia, Luisa; Rouzier, Régine; Guillaume, Maeva; Hodge, Alexander; Romero-Gómez, Manuel; Huot-Marchand, Philippe; Baudin, Martine; Richard, Marie-Paule; Abitbol, Jean-Louis; Broqua, Pierre; Junien, Jean-Louis; Abdelmalek, Manal F. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH. New England Journal of Medicine. 21 October 2021, 385 (17): 1547–1558 [2023-11-23]. ISSN 0028-4793. doi:10.1056/NEJMoa2036205 . （原始内容存档于2023-11-23）（英语）.

[Harrison-4] Harrison, Stephen A.; Loomba, Rohit; Dubourg, Julie; Ratziu, Vlad; Noureddin, Mazen. Clinical Trial Landscape in NASH. Clinical Gastroenterology and Hepatology. July 2023, 21 (8): 2001–2014. doi:10.1016/j.cgh.2023.03.041.

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