CXCL11

Chemokine (C-X-C motif) ligand 11
Chemokine (C-X-C motif) ligand 11
	PDB rendering based on 1rjt.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1RJT
标识
代号	CXCL11; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
扩展标识	遗传学：604852 鼠基因：1860203 同源基因：3944 GeneCards: CXCL11 Gene
基因本体论描述
分子功能	· chemokine activity;
细胞成分	· extracellular region; · extracellular space;
生物过程	· chemotaxis; · inflammatory response; · immune response; · signal transduction; · cell-cell signaling;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6373
Ensembl	ENSG00000169248
UniProt	O14625
mRNA序列	NM_005409
蛋白序列	NP_005400
基因位置	Chr 4:; 76.95 – 76.96 Mb
PubMed查询	[1]
	查; 论; 编;

CXCL11（英語：Chemokine (C-X-C motif) ligand 11）是一小分子的细胞因子属于CXC趋化因子家族^[1]，又被称作“干扰素诱导的T细胞a趋化因子”（Interferon-inducible T-cell alpha chemoattractant (I-TAC)^[1]。

表达

在白细胞，胰腺和肝脏中表达水平高，在胸腺，脾和肺有中等水平的表达，在小肠，胎盘和前列腺中表达水平低^[1]。干扰素伽玛和干扰素－b可以在单核细胞^[1]，支气管上皮细胞^[2]，中性粒细胞^[3]，角质形成细胞^[4]，和内皮细胞诱导CXCL11的表达。

受体

CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用^[1]^[5]^[6]。CXCL11也可以结合到趋化因子受体CCR3上而阻止CCR3配体的结合^[7]。

功能

CXCL11对活化的T细胞，中性粒细胞和单核细胞有细胞趋化作用^[1]。

参见

参考文献

^ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
^ Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
^ Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
^ Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
^ Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）

[cole-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.

[sau-2] Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558

[gas-3] Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.

[ten-4] Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.

[5] Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[6] Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

[loe-7] Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91

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