饥饿反应
饥饿反应（starvation response）是动物（包括人类）的一组适应性生化和生理变化，由缺乏食物或极度体重减轻引发，其中身体试图通过减少燃烧的卡路里量来节省能量[1]。当营养物质有限时，细菌会对抗生素产生高度耐受性。饥饿有助于感染期间的抗生素耐受性，因为当营养物质被宿主防御隔离并被增殖细菌消耗时，营养物质变得有限[2][3]。体内饥饿诱导耐受的最重要原因之一是生物膜生长，这发生在许多慢性感染中[4][5][6]。生物膜中的饥饿是由于位于生物膜簇外围的细胞消耗营养以及减少底物通过生物膜的扩散[7]。生物膜细菌对几乎所有抗生素类别都表现出极强的耐受性，提供限制性底物可以恢复敏感性[8]。
参考文献
[编辑]- ^ Is Starvation Mode Real or Imaginary? A Critical Look. healthline. June 19, 2021 [2022-07-26]. （原始内容存档于2022-07-26）. （页面存档备份，存于互联网档案馆）
- ^ McDERMOTT, W. Microbial persistence.. The Yale Journal of Biology and Medicine. February 1958, 30 (4): 257–91. PMC 2603844
. PMID 13531168.
- ^ McCune, Robert M.; Dineen, Paul A. Peter; Batten, John C. The Effect of Antimicrobial Drugs on an Experimental Staphylococcal Infection in Mice. Annals of the New York Academy of Sciences. August 1956, 65 (3): 91–102. Bibcode:1956NYASA..65...91M. PMID 13363203. S2CID 40134313. doi:10.1111/j.1749-6632.1956.tb36627.x.
- ^ Fux, C.A.; Costerton, J.W.; Stewart, P.S.; Stoodley, P. Survival strategies of infectious biofilms. Trends in Microbiology. January 2005, 13 (1): 34–40. PMID 15639630. doi:10.1016/j.tim.2004.11.010.
- ^ Lewis, Kim. Persister cells, dormancy and infectious disease. Nature Reviews Microbiology. 4 December 2006, 5 (1): 48–56. PMID 17143318. S2CID 6670040. doi:10.1038/nrmicro1557.
- ^ Parsek, Matthew R.; Singh, Pradeep K. Bacterial Biofilms: An Emerging Link to Disease Pathogenesis. Annual Review of Microbiology. October 2003, 57 (1): 677–701. PMID 14527295. doi:10.1146/annurev.micro.57.030502.090720.
- ^ Stewart, PS; Franklin, MJ. Physiological heterogeneity in biofilms.. Nature Reviews. Microbiology. March 2008, 6 (3): 199–210. PMID 18264116. S2CID 5477887. doi:10.1038/nrmicro1838.
- ^ Borriello, G; Richards, L; Ehrlich, GD; Stewart, PS. Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms.. Antimicrobial Agents and Chemotherapy. January 2006, 50 (1): 382–4. PMC 1346784 . PMID 16377718. doi:10.1128/AAC.50.1.382-384.2006 .
