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A-84543

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A-84543
识别信息
  • 3-[[(2S)-1-Methyl-2-pyrrolidinyl]methoxy}pyridine
CAS号161416-43-9  checkY[NIH]
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C11H16N2O
摩尔质量192.26 g·mol−1
3D模型(JSmol英语JSmol
  • CN1CCC[C@H]1COc2cccnc2
  • InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1 ☒N
  • Key:MVLJPWPLDPHKST-JTQLQIEISA-N ☒N

A-84543是一种含氮有机化合物,分子式C11H16N2O,是美国雅培公司研发的烟碱型乙酰胆碱受体激动剂,能作为开发相关化合物的先导化合物[1][2][3][4]

参考文献

[编辑]
  1. ^ Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, et al. Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. February 1996, 39 (4): 817–25. PMID 8632405. doi:10.1021/jm9506884. 
  2. ^ Lin NH, Gunn DE, Li Y, He Y, Bai H, Ryther KB, et al. Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. Bioorganic & Medicinal Chemistry Letters. February 1998, 8 (3): 249–54. PMID 9871663. doi:10.1016/S0960-894X(98)00019-5. 
  3. ^ Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, et al. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. March 2005, 48 (6): 1721–4. PMID 15771418. doi:10.1021/jm0492406. 
  4. ^ Carreras J, Avenoza A, Busto JH, Peregrina JM. Synthesis of azabicyclo[2.2.n]alkane systems as analogues of 3-[1-methyl-2-(S)-pyrrolidinyl- methoxy]pyridine (A-84543). The Journal of Organic Chemistry. April 2007, 72 (8): 3112–5. PMID 17371077. doi:10.1021/jo0700732.