APINACA

APINACA
法律規範狀態
法律規範	Temporary Class Drug (NZ), illegal in Japan;
識別資訊
	IUPAC命名法 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide; ;
CAS號	1345973-53-6
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID90928683 ;
化學資訊
化學式	C23H31N3O
摩爾質量	365.52 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C3C4CC2CC3CC(C4)(C2)NC(=O)c(nn1CCCCC)c5c1cccc5;

AKB48（APINACA, N-(1-金剛烷)-1-戊基-1H-吲唑-3-甲酰胺）是一種潛在的大麻素受體激動劑。此前它從未在科學界或專利文獻中被報道過，2012年3月在日本的實驗室中作為合成大麻混合煙的原料被識別出來^[1]。結構上它類似於專利號為WO 2003/035005（頁面存檔備份，存於網際網路檔案館）的大麻素化合物，除了吲唑1位上引入了一條戊烷基鏈，因而APINACA應屬於該專利所涵蓋的範圍，儘管尚未作為實例得到確認。APINACA於2012年在日本被宣布為非法藥物^[2]，從2012年7月13日起作為臨時類毒品在新西蘭被禁止。^[3]

參見

參考文獻

^ Nahoko Uchiyama; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products. Forensic Toxicology. 2012-04-10, 30 (2): 114–125. doi:10.1007/s11419-012-0136-7.
^ Designation of “Shitei Yakubutsu” (designated substances) based on the provision of the Pharmaceutical Affairs Law (1960, Law No.145) (PDF). [2012-07-17]. （原始內容存檔 (PDF)於2019-02-15）.
^ Temporary Class Drug Notice, 05 July 2012. NZ Department of Internal Affairs.. [2012-07-17]. （原始內容存檔於2013-06-15）.

[1] Nahoko Uchiyama; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products. Forensic Toxicology. 2012-04-10, 30 (2): 114–125. doi:10.1007/s11419-012-0136-7.

[2] Designation of “Shitei Yakubutsu” (designated substances) based on the provision of the Pharmaceutical Affairs Law (1960, Law No.145) (PDF). [2012-07-17]. （原始內容存檔 (PDF)於2019-02-15）.

[3] Temporary Class Drug Notice, 05 July 2012. NZ Department of Internal Affairs.. [2012-07-17]. （原始內容存檔於2013-06-15）.

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