表皮生長因子

表皮生長因子（β-尿抑胃素）
表皮生長因子（β-尿抑胃素）
	Rainbow colored NMR structure (N-terminus = blue, C-terminus = red) of the mouse epidermal growth factor.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	human: 1JL9, 1IVO and 1NQL in complex with EGFR; mouse: 1EGF, 3EGF, 1EPG, 1EPH, 1EPI, 1EPJ; human EGF/TGF-α chimera: 1P9J; synthetic: 1A3P
標識
代號	EGF; URG
擴展標識	遺傳學：131530 鼠基因：95290 同源基因：1483 GeneCards: EGF Gene
基因本體論描述
分子功能	· epidermal growth factor receptor-activating ligand activity; · calcium ion binding; · protein binding; · growth factor activity;
細胞成分	· extracellular region; · extracellular space; · nucleus; · plasma membrane; · integral to membrane;
生物過程	· activation of MAPKK activity; · activation of MAPK activity; · DNA replication; · chromosome organization and biogenesis (sensu Eukaryota); · epidermal growth factor receptor signaling pathway; · positive regulation of cell proliferation; · branching morphogenesis of a tube; · regulation of peptidyl-tyrosine phosphorylation;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	1950
Ensembl	ENSG00000138798
UniProt	P01133
mRNA序列	NM_001963
蛋白序列	NP_001954
基因位置	Chr 4:; 111.05 – 111.15 Mb
PubMed查詢	[1]
	閱; 論; 編;

表皮生長因子（英語：Epidermal growth factor，簡稱：EGF）是最早發現的生長因子，對調節細胞生長、增殖和分化起着重要作用。在人類，表皮生長因子蛋白有53個氨基酸殘基，三個二硫鍵，質量6千道耳頓。^[2]

表皮生長因子通過與細胞表面的受體表皮生長因子受體（EGFR）結合而起作用。^[3]與表皮生長因子受體的高親和力結合，激發受體內在的酪氨酸激酶的活性，從而啟動了信號傳導級聯而導致多種生物化學變化，細胞內鈣水平上升，增加糖酵解與蛋白質合成，增加某些基因（包括表皮生長因子受體）的表達，最終導致DNA合成和細胞增殖。^[2]

參考文獻

^ PDB 1a3p; Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS. Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science. August 1998, 7 (8): 1738–49. PMC 2144085 . PMID 10082370. doi:10.1002/pro.5560070808.
^ ^2.0 ^2.1 Epidermal growth factor. J Biol Chem. 1990; 265(14): 7709-12.
^ Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

外部連結

Human Protein Database=表皮生長因子（頁面存檔備份，存於互聯網檔案館）
MeSH 表皮生長因子(英文)（頁面存檔備份，存於互聯網檔案館）
Shaanxi Zhongbang Pharma-Tech Co., Ltd.-Supply of Epidermal Growth Factor（頁面存檔備份，存於互聯網檔案館）
EGF at the Human Protein Reference Database.
醫學主題詞表（MeSH）：Epidermal+growth+factor
EGF model in BioModels database（頁面存檔備份，存於互聯網檔案館）

[pmid10082370-1] PDB 1a3p; Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS. Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science. August 1998, 7 (8): 1738–49. PMC 2144085 . PMID 10082370. doi:10.1002/pro.5560070808.

[cohen-2] 2.0 ^2.1 Epidermal growth factor. J Biol Chem. 1990; 265(14): 7709-12.

[3] Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

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