磷酸葡萄糖酸脱氢酶 (脱羧)

磷酸葡萄糖酸脱氢酶 (脱羧)
命名 系统命名 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) 缩写 别名 phosphogluconic acid dehydrogenase; 6-phosphogluconic dehydrogenase; 6-phosphogluconic carboxylase; 6-phosphogluconate dehydrogenase (decarboxylating); 6-phospho-D-gluconate dehydrogenase
识别码
EC编号	1.1.1.44
CAS号	9073-95-4
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
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磷酸葡萄糖酸脱氢酶 (脱羧)（英语：phosphogluconate dehydrogenase (decarboxylating)，EC 1.1.1.44 （页面存档备份，存于互联网档案馆））是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

6-磷酸-D-葡萄糖酸 + NADP⁺ $\rightleftharpoons$ D-核酮糖5-磷酸 + CO₂ + NADPH

在上述反应中，6-磷酸葡萄糖酸首先被氧化为3-酮-6-磷酸葡萄糖酸，同时NADPH形成并被释放；然后，中间体被脱羧产生1,2-烯二醇式结构，最终互变异构化为核酮糖5-磷酸。 高浓度的NADPH对这种酶的活性有抑制性，而6-磷酸葡萄糖酸则能激活这种酶。 磷酸葡萄糖酸脱氢酶 (脱羧)主要参与核酮糖5-磷酸的产生，并为磷酸戊糖途径提供主要的NADPH。

参考文献

• DICKENS F, GLOCK GE. Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphates by enzymes of animal origin. Biochem. J. 1951, 50 (1): 81–95. PMC 1197610 . PMID 14904376. 
• Bonsignore A and Horecker BL. Purification and properties of beta-L-hydroxy acid dehydrogenase II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis. J. Biol. Chem. 1961, 236: 2975–2980. 
• Scott DBM and Cohen SS. The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Biochem. J. 1953, 55: 23–33. 
• Scott DBM and Cohen SS. The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli. Biochem. J. 1957, 65: 686–689.