2-氟-6-氯苯甲醛

2-氟-6-氯苯甲醛
	IUPAC名; 2-chloro-6-fluorobenzaldehyde
识别
CAS号	387-45-1
PubChem	67847
ChemSpider	61164
SMILES	C1=CC(=C(C(=C1)Cl)C=O)F;
InChI	1S/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H;
EINECS	206-860-5
性质
化学式	C7H4ClFO
摩尔质量	158.56 g·mol−1
外观	白色晶体
熔点	33 - 35 °C
溶解性（水）	难溶于水
溶解性	可溶于甲醇、乙醇
危险性
	GHS危险性符号;
GHS提示词	警告
H-术语	H315, H319, H335, H401
P-术语	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P321, P362+364, P403+233, P405, P501
NFPA 704	0 2
闪点	101 °C
相关物质
相关化学品	2-氟-6-氯苯甲醛肟
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2-氟-6-氯苯甲醛是一种有机化合物，化学式为C₇H₄ClFO。它可由2-氟-4-氯苯甲醇经N-甲基吗啉氯铬酸盐（或过硫酸钾^[1]）在一定条件下氧化制得。^[2]也有文献通过2,6-二氯苯甲醛的氟化反应^[3]^[4]或2-氟-α,α,6-三氯甲苯的水解反应^[5]制得。它可以和丙二腈发生Knoevenagel反应。^[6]

参考文献

^ A. C. Chaskar, S. R. Bhandari, A. B. Patil, O. P. Sharma, S. Mayeker. Solvent-Free Oxidation of Alcohols with Potassium Persulphate in the Presence of Brönsted Acidic Ionic Liquids. Synthetic Communications. 2008-12-31, 39 (2): 366–370 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802374117 （英语）.
^ S. Chandrappa, M. P. Sadashiva, K. S. Rangappa. N -Methyl Morpholine Chlorochromate: An Efficient Reagent for Oxidation of Primary and Secondary Alcohols to Carbonyl Compounds. Synthetic Communications. 2008-07-24, 38 (15): 2638–2645 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802219502 （英语）.
^ Wild, Jochen; Goetz, Norbert. Fluorination of chlorobenzaldehydes with alkali metal fluorides in the presence of phase transfer catalysts. 1989 DE 3820979 A1.
^ A. Pleschke, A. Marhold, M. Schneider, A. Kolomeitsev, G.-V. Röschenthaler. Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: a comparative study. Journal of Fluorine Chemistry. 2004-06, 125 (6): 1031–1038 [2022-03-16]. doi:10.1016/j.jfluchem.2004.01.030. （原始内容存档于2018-06-29）（英语）.
^ Billeb, Gilbert; Burg, Peter. Process for the preparation of aromatic aldehydes. 1994 EP 599241 A1.
^ Shoaib Muhammad, Muhammad Naveed Javed, Firdous Imran Ali, Ahmed Bari, Imran Ali Hashmi. Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids. Journal of Molecular Liquids. 2020-02, 300: 112372 [2022-03-16]. doi:10.1016/j.molliq.2019.112372 （英语）.

[1] A. C. Chaskar, S. R. Bhandari, A. B. Patil, O. P. Sharma, S. Mayeker. Solvent-Free Oxidation of Alcohols with Potassium Persulphate in the Presence of Brönsted Acidic Ionic Liquids. Synthetic Communications. 2008-12-31, 39 (2): 366–370 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802374117 （英语）.

[2] S. Chandrappa, M. P. Sadashiva, K. S. Rangappa. N -Methyl Morpholine Chlorochromate: An Efficient Reagent for Oxidation of Primary and Secondary Alcohols to Carbonyl Compounds. Synthetic Communications. 2008-07-24, 38 (15): 2638–2645 [2022-03-16]. ISSN 0039-7911. doi:10.1080/00397910802219502 （英语）.

[3] Wild, Jochen; Goetz, Norbert. Fluorination of chlorobenzaldehydes with alkali metal fluorides in the presence of phase transfer catalysts. 1989 DE 3820979 A1.

[4] A. Pleschke, A. Marhold, M. Schneider, A. Kolomeitsev, G.-V. Röschenthaler. Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: a comparative study. Journal of Fluorine Chemistry. 2004-06, 125 (6): 1031–1038 [2022-03-16]. doi:10.1016/j.jfluchem.2004.01.030. （原始内容存档于2018-06-29）（英语）.

[5] Billeb, Gilbert; Burg, Peter. Process for the preparation of aromatic aldehydes. 1994 EP 599241 A1.

[6] Shoaib Muhammad, Muhammad Naveed Javed, Firdous Imran Ali, Ahmed Bari, Imran Ali Hashmi. Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids. Journal of Molecular Liquids. 2020-02, 300: 112372 [2022-03-16]. doi:10.1016/j.molliq.2019.112372 （英语）.

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