5-氨基-1,3,4-噻二唑-2-硫酮

5-氨基-1,3,4-噻二唑-2-硫酮
别名	2-氨基-5-巯基-1,3,4-噻二唑
识别
CAS号	2349-67-9
性质
化学式	C2H3N3S2
摩尔质量	133.2 g·mol−1
外观	黄色晶体
熔点	236—238 °C（509—511 K）（分解）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

5-氨基-1,3,4-噻二唑-2-硫酮是一种有机化合物，化学式为C₂H₃N₃S₂。它可由氨基硫脲（英语：Thiosemicarbazide）和二硫化碳在DMF中回流^[2]或碳酸钠存在下于乙醇中回流^[3]反应得到。它和异氰酸苯酯反应，可以得到N-苯基-N'-(5-巯基-1,3,4-噻二唑-2-基)脲。^[4]它和丙炔酸甲酯在水中加热反应，可以得到3-(5-氨基-1,3,4-噻二唑-2-硫基)丙烯酸甲酯。^[5]

参考文献

^ ^1.0 ^1.1 S. Talath, A.K. Gadad. Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives. European Journal of Medicinal Chemistry. 2006-08, 41 (8): 918–924 [2023-02-27]. doi:10.1016/j.ejmech.2006.03.027. （原始内容存档于2023-03-15）（英语）.
^ You-Ming Zhang, Ming-Xia Liu, Qi Lin, Qiao Li, Tai-Bao Wei. Mercapto Thiadiazole-based Sensors with High Selectivity and Sensitivity for Hg 2 + in Aqueous Solution. Journal of Chemical Research. 2010-11, 34 (11): 619–621 [2023-02-27]. ISSN 1747-5198. doi:10.3184/030823410X12876712319282. （原始内容存档于2023-02-26）（英语）.
^ Vaibhav Dubey, Manish Pathak, Hans R. Bhat, Udaya P. Singh. Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge: Antibacterial Activity of 1,3,5-triazines. Chemical Biology & Drug Design. 2012-10, 80 (4): 598–604 [2023-02-27]. doi:10.1111/j.1747-0285.2012.01433.x. （原始内容存档于2023-02-26）（英语）.
^ Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed. Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023-12-31, 38 (1) [2023-02-27]. ISSN 1475-6366. doi:10.1080/14756366.2022.2162511. （原始内容存档于2023-02-26）（英语）.
^ Haiying Wang, Jiewei Rong. An Efficient Catalyst-Free Synthesis of Vinyl Sulfides in Aqueous-Phase. HETEROCYCLES. 2022, 104 (12) [2023-02-27]. ISSN 0385-5414. doi:10.3987/COM-22-14736. （原始内容存档于2023-02-26）（英语）.

[Talath-1] 1.0 ^1.1 S. Talath, A.K. Gadad. Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives. European Journal of Medicinal Chemistry. 2006-08, 41 (8): 918–924 [2023-02-27]. doi:10.1016/j.ejmech.2006.03.027. （原始内容存档于2023-03-15）（英语）.

[2] You-Ming Zhang, Ming-Xia Liu, Qi Lin, Qiao Li, Tai-Bao Wei. Mercapto Thiadiazole-based Sensors with High Selectivity and Sensitivity for Hg 2 + in Aqueous Solution. Journal of Chemical Research. 2010-11, 34 (11): 619–621 [2023-02-27]. ISSN 1747-5198. doi:10.3184/030823410X12876712319282. （原始内容存档于2023-02-26）（英语）.

[3] Vaibhav Dubey, Manish Pathak, Hans R. Bhat, Udaya P. Singh. Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge: Antibacterial Activity of 1,3,5-triazines. Chemical Biology & Drug Design. 2012-10, 80 (4): 598–604 [2023-02-27]. doi:10.1111/j.1747-0285.2012.01433.x. （原始内容存档于2023-02-26）（英语）.

[4] Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed. Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023-12-31, 38 (1) [2023-02-27]. ISSN 1475-6366. doi:10.1080/14756366.2022.2162511. （原始内容存档于2023-02-26）（英语）.

[5] Haiying Wang, Jiewei Rong. An Efficient Catalyst-Free Synthesis of Vinyl Sulfides in Aqueous-Phase. HETEROCYCLES. 2022, 104 (12) [2023-02-27]. ISSN 0385-5414. doi:10.3987/COM-22-14736. （原始内容存档于2023-02-26）（英语）.

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