6-氯烟碱
| 6-氯烟碱 | |
|---|---|
| |
| 识别 | |
| CAS号 | 112091-17-5 
|
| 性质 | |
| 化学式 | C10H13ClN2 |
| 摩尔质量 | 196.68 g·mol−1 |
| 密度 | 1.162±0.06 g·cm−3（20 °C）[1] |
| 溶解性（水） | 1.1 g（25 °C）[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
6-氯烟碱是一种有机化合物，化学式为C10H13ClN2。它可由烟碱经过氧化氢氧化，得N-氧化烟碱，加入三氯氧磷后反应制得，副产物2-氯烟碱可以通过加入二异丙胺抑制产生（<1%）。[2]烟碱在−78 °C和正丁基锂反应，再和六氯乙烷反应也可以得到6-氯烟碱。[3]它和正丁醇在碳酸铯和催化剂的存在下于甲苯中反应，可以得到6-丁氧基烟碱。[4]
参考文献
[编辑]- ^ 1.0 1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-01-15].
- ^ Boris Schmidt, Vera Neitemeier. 6-Pyridylnicotine and Bis-6,6′-nicotine - New Chiral 2,2′-Bipyridines. Synthesis. 1998-01, 1998 (01): 42–44 [2021-01-15]. doi:10.1055/s-1998-1997. （原始内容存档于2018-06-07）.
- ^ David C. Pryde, Lyn H. Jones, David P. Gervais, David R. Stead, David C. Blakemore, Matthew D. Selby, Alan D. Brown, Jotham W. Coe, Matthew Badland, David M. Beal, Rebecca Glen, Yvonne Wharton, Gavin J. Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R. Merson, Heather L. Davis, Michael J. McCluskie. Kim D. Janda , 编. Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice. PLoS ONE. 2013-10-01, 8 (10): e76557 [2021-01-15]. ISSN 1932-6203. PMC 3788104
. PMID 24098532. doi:10.1371/journal.pone.0076557 （英语）.
- ^ Ondachi, Pauline Wanjiku (North Carolina State Univ. Raleigh, NC, USA). Synthesis of alkoxy, heterocyclic and fused-rings derivatives of (S)-nicotine from natural nicotine, progress towards the total synthesis of (S)-macrostomine. Diss. Abstr. Int., B, 2009 70 (2). DA3345428.
