SNARE蛋白

SNARE-fusion membrane complex proteins
SNARE-fusion membrane complex proteins
鉴定
标志	SNARE
InterPro（英语：InterPro）	IPR010989
SCOP（英语：Structural Classification of Proteins）	1kil / SUPFAM
TCDB（英语：TCDB）	1.F.1
OPM（英语：Orientations of Proteins in Membranes database）家族	197
OPM（英语：Orientations of Proteins in Membranes database）蛋白	3hd7
膜蛋白数据库（英语：Membranome）	198

Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and closely regulates the SNARE zipping.^[1]

可溶性N-乙基马来酰亚胺敏感性因子附着蛋白受体（英语：SNAP REceptor，即SNAP受体，又称可溶性NSF附着蛋白受体），又称SNARE蛋白，是一个大的蛋白质家族，由酵母菌中的至少24个成员和哺乳动物细胞中的60个以上的成员组成。^[2]^[3]SNARE蛋白的主要作用是介导囊泡融合以及囊泡与靶膜的融合。这尤其介导胞吐作用，但也可以介导囊泡与膜结合区室（如溶酶体）的融合。研究最深入的SNARE是介导神经元中突触小泡的神经递质释放。这些神经元SNAREs是负责某些细菌产生的肉毒杆菌中毒和破伤风的等神经毒素的标靶。

参考资料

^ Georgiev, Danko D; James F . Glazebrook. Subneuronal processing of information by solitary waves and stochastic processes. Lyshevski, Sergey Edward (编). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. 2007: 17–1–17–41 [2020-10-09]. ISBN 978-0-8493-8528-5. doi:10.1201/9781420008142.ch17 (不活跃 2020-09-09). （原始内容存档于2016-01-16）.
^ Burri, Lena; Lithgow, Trevor. A complete set of SNAREs in yeast. Traffic. 2004-01-01, 5 (1): 45–52. ISSN 1398-9219. PMID 14675424. doi:10.1046/j.1600-0854.2003.00151.x.
^ Gerald K. Cell and Molecular Biology 4th. John Wiley & Sons. 2002.

外部链接

[Georgiev2007-1] Georgiev, Danko D; James F . Glazebrook. Subneuronal processing of information by solitary waves and stochastic processes. Lyshevski, Sergey Edward (编). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. 2007: 17–1–17–41 [2020-10-09]. ISBN 978-0-8493-8528-5. doi:10.1201/9781420008142.ch17 (不活跃 2020-09-09). （原始内容存档于2016-01-16）.

[2] Burri, Lena; Lithgow, Trevor. A complete set of SNAREs in yeast. Traffic. 2004-01-01, 5 (1): 45–52. ISSN 1398-9219. PMID 14675424. doi:10.1046/j.1600-0854.2003.00151.x.

[gerald2002-3] Gerald K. Cell and Molecular Biology 4th. John Wiley & Sons. 2002.

[1]

[2]

[3]