4-硝基氟苯
外觀
4-硝基氟苯 | |
---|---|
識別 | |
CAS號 | 350-46-9 |
性質 | |
化學式 | C6H4FNO2 |
摩爾質量 | 141.1 g·mol−1 |
密度 | 1.33 g·cm−3(20 °C)[1] |
熔點 | 27 °C(300 K)[1] 21 °C(294 K)[2] |
沸點 | 206—207 °C(479—480 K)[1] 205 °C(478 K)[2] |
相關物質 | |
相關化學品 | 4-硝基氯苯 4-硝基溴苯 4-硝基碘苯 2-硝基氟苯 3-硝基氟苯 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
4-硝基氟苯是一種有機化合物,化學式為C6H4FNO2。
製備
[編輯]4-硝基氟苯可由4-硝基氯苯和氟化鉀在PPNCl催化下於二甲基亞碸中進行鹵素交換反應製得。[3]
硝酸和三氟乙酸酐在Hβ沸石的存在下對氟苯進行硝化,可以得到4-硝基氟苯,副產物為2-硝基氟苯,占比8%,若在反應體系中另加入乙酸酐,可使鄰位的副產物降至1%以下。[4]
性質
[編輯]在鎳催化下,氫氣或硼氫化鈉可將其還原為4-氟苯胺。[5][6]它和N-甲基哌嗪發生偶聯反應,可以得到1-甲基-4-(4-硝基苯基)哌嗪。[7]
參考文獻
[編輯]- ^ 1.0 1.1 1.2 "Hazardous Substances Data Bank" data were obtained from the National Library of Medicine (US). Retrieved from SciFinder. [2021-11-24].
- ^ 2.0 2.1 "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2021-11-24].
- ^ Marie-Agnès Lacour, Maria Zablocka, Carine Duhayon, Jean-Pierre Majoral, Marc Taillefer. Efficient Phosphorus Catalysts for the Halogen-Exchange (Halex) Reaction. Advanced Synthesis & Catalysis. 2008-11-14, 350 (17): 2677–2682 [2021-11-24]. doi:10.1002/adsc.200800428. (原始內容存檔於2021-11-24) (英語).
- ^ Keith Smith, Tracy Gibbins, Ross W. Millar, Robert P. Claridge. A novel method for the nitration of deactivated aromatic compounds †. Journal of the Chemical Society, Perkin Transactions 1. 2000, (16): 2753–2758 [2021-11-24]. doi:10.1039/b002158j.
- ^ Qingjie Tang, Ziliang Yuan, Shiwei Jin, Kaiyue Yao, Hanmin Yang, Quan Chi, Bing Liu. Biomass-derived carbon-supported Ni catalyst: an effective heterogeneous non-noble metal catalyst for the hydrogenation of nitro compounds. Reaction Chemistry & Engineering. 2020, 5 (1): 58–65 [2021-11-24]. ISSN 2058-9883. doi:10.1039/C9RE00366E (英語).
- ^ Mahsa Niakan, Zahra Asadi. Selective Reduction of Nitroarenes Catalyzed by Sustainable and Reusable DNA-supported Nickel Nanoparticles in Water at Room Temperature. Catalysis Letters. 2019-08, 149 (8): 2234–2246 [2021-11-24]. ISSN 1011-372X. doi:10.1007/s10562-019-02741-7 (英語).
- ^ Pu Xiang, Tian Zhou, Liang Wang, Chang-Yan Sun, Jing Hu, Ying-Lan Zhao, Li Yang. Novel Benzothiazole, Benzimidazole and Benzoxazole Derivatives as Potential Antitumor Agents: Synthesis and Preliminary in Vitro Biological Evaluation. Molecules. 2012-01-17, 17 (1): 873–883 [2021-11-24]. ISSN 1420-3049. PMC 6268746 . PMID 22252503. doi:10.3390/molecules17010873. (原始內容存檔於2022-03-13) (英語).