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Ro67-4853

维基百科，自由的百科全书
Ro67-4853
Ro67-4853 2D skeltal
Ro67-4853 3D BS
识别信息
  • butyl (9H-xanthene-9-carbonyl)carbamate
CAS号302841-89-0
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C19H19NO4
摩尔质量325.36 g·mol−1
3D模型（JSmol（英语：JSmol））
  • c3cccc2c3Oc1ccccc1C2C(=O)NC(=O)OCCCC
  • InChI=1S/C19H19NO4/c1-2-3-12-23-19(22)20-18(21)17-13-8-4-6-10-15(13)24-16-11-7-5-9-14(16)17/h4-11,17H,2-3,12H2,1H3,(H,20,21,22)
  • Key:RQBUXEUMZZQUFY-UHFFFAOYSA-N

Ro67-4853是一种含氮有机化合物，化学式为C19H19NO4，作为代谢型谷氨酸受体的mGluR1亚型的别构调节剂用于科学研究。[1][2][3]

参考文献

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  1. ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proceedings of the National Academy of Sciences of the United States of America. November 2001, 98 (23): 13402–7. Bibcode:2001PNAS...9813402K. PMC 60883 可免费查阅. PMID 11606768. doi:10.1073/pnas.231358298 可免费查阅. 
  2. ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators (PDF). Molecular Pharmacology. August 2006, 70 (2): 616–626. PMID 16645124. S2CID 2719603. doi:10.1124/mol.105.021857. （原始内容 (PDF)存档于2019-02-22）. 
  3. ^ Sheffler DJ, Conn PJ. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. September 2008, 55 (4): 419–27. PMC 2600811 可免费查阅. PMID 18625258. doi:10.1016/j.neuropharm.2008.06.047. 

外部链接

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